Disease related

anti-Cadherin 6 mouse monoclonal, 2B6, supernatant

Cat. No: 16111

Available, delivery time 1-7 days

$306.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC on frozen sections
  • Reacts with human
  • Isotype: IgG1
Product description
Quantity 1 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Application IHC
Purification Hybridoma cell culture supernatant
Reactivity Human
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone 2B6
Immunogen GST fusion protein of part of the extracellular domain of cadherin 6 (K-Cadherin)
Formulation Contains 0.09% sodium azide
UniprotID P55285 (Human)
Synonym Cadherin-6, Kidney cadherin, K-cadherin, CDH6
Note Centrifuge prior to opening
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen Ready-to-use (paraformaldehyde fixed; with 0.2% Triton X-100 in PBS)
Background

The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12.
During embryogenesis differential expression of cadherins can drive morphogenesis by stimulating cell aggregation, defining boundaries between groups of cells and promoting cell migration. Cadherin-6 seems to be required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithelium.

Positive control: Embryonic kidney (e.g. establishment of developmental pattern of nephrons)

References/Publications (2)
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