anti-Arginase-1 mouse monoclonal, IHC400, purified
- Mouse monoclonal
- Suitable for IHC
- Reacts with human
- Isotype: IgG2b
|Intended use||Research use only|
|Immunogen||Recombinant Human Arginase-1|
|Formulation||Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide|
|Synonym||Arginase-1, EC 184.108.40.206, Liver-type arginase, Type I arginase, ARG1
|Tested applications||Tested dilutions|
|Immunohistochemistry (IHC) - paraffin||1:50-1:200 (microwave treatment recommended)|
Arginase-1, encoded by the ARG1 gene, is a cytosolic metalloenzyme expressed predominantly in hepatocytes. Arginase-1 plays a key role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Argininemia is an inherited autosomal recessive disorder characterized by a buildup of arginine and ammonia in the blood. Anti-Arginase-1 is highly specific for hepatocytes, and is therefore a sensitive and specific marker of benign and malignant hepatic tumours.
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