Diagnostic marker

anti-BCL10 mouse monoclonal, EBS-T-001, purified

Cat. No: 691671

Available, delivery time 1-7 days

$425.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with human
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application IHC, WB
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone EBS-T-001
Immunogen Human BCL10 recombinant protein (aa122-168)
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID O95999 (Human)
Synonym B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml; microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)
Background

EBS-T-001 reacts with BCL10. Having a N-terminal caspase recruitment domain (CARD), BCL10 can induce apoptosis and activate NF-kappaB. It is found on subpopulations of normal B and T cells, and is associated with MALT1, a paracaspase that, like BCL10, can be found translocated in MALT lymphoma. In such cases either BCL10 or MALT1 or both are highly expressed, depending on the site of translocation. MALT lymphomas lacking this translocation exhibit much lower levels of expression. BCL10 has been shown to be functionally conserved all the way back to zebrafish.

Positive control: HepG2 cells or lymphoma.

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