Diagnostic marker

anti-CD11b mouse monoclonal, EBS-CD-010, purified

Cat. No: 691560

Available, delivery time 1-7 days

$425.00*

Key Features
  • Mouse monoclonal
  • Suitable for FACS, ICC/IF and IHC
  • Reacts with human
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application FACS, ICC/IF, IHC
Purification Affinity chromatography
Reactivity Human
No reactivity Mouse
Storage 2-8°C
Intended use Research use only
Clone EBS-CD-010
Immunogen Human neutrophils
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID P11215 (Human)
Synonym Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD antigen CD11b, ITGAM, CD11B, CR3A
Applications
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:100-1:200 (0.5-1.0 µg/ml)
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Flow Cytometry (FACS) 0.5-1.0 µg/million cells in 0.1 ml
Background

Integrin alpha-M (also designated complement component receptor 3 alpha chain; CD11b (p170); macrophage antigen alpha polypeptide; cell surface glycoprotein Mac-1 alpha-subunit; CR3 alpha-chain; MAC1A; MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an alpha chain and a beta chain. Integrin alpha-M combines with integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor-1 (Mac-1) or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M-beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

Positive control: human monocytes and granulocytes. Human lymph node and tonsil.

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