Disease related

anti-CD46 mouse monoclonal, 197-2B1, purified

Cat. No: 691589

Available, delivery time 1-7 days


Key Features
  • Mouse monoclonal
  • Suitable for FACS, ICC/IF and IHC
  • Reacts with human
  • Isotype: IgG2a kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG2a kappa
Conjugate Unconjugated
Application FACS, ICC/IF, IHC
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone 197-2B1
Immunogen Stimulated human leucocytes
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID P15529 (Human)
Synonym Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD antigen CD46, CD46, MCP, MIC10
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:100-1:200 (0.5-1.0 µg/ml)
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Flow Cytometry (FACS) 0.5-1.0 µg/million cells in 0.1 ml

197-2B1 reacts with human CD46, a 52-58 kDa single chain type 1 transmembrane molecule. CD46 is a cofactor for the factor I regulation of complement components C3b and C4b and contains four N-terminal short consensus repeat (SCR) modules. It is strongly expressed on salivary gland ducts and kidney ducts and often increased on tumor cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. 197-2B1 has been clustered at the VIth HLDA Workshop.

Positive control: K562, U937, HL60, HeLa and Jurkat cells, and human lymphocytes. Lymph node and tonsil.

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