Disease related

anti-CRASH mouse monoclonal, 7B6, purified

Cat. No: 691516

Available, delivery time 1-7 days

$425.00*

Key Features
  • Mouse monoclonal
  • Suitable for ELISA, IHC and WB
  • Reacts with human
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application ELISA, IHC, WB
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone 7B6
Immunogen With CRASH recombinant protein and synthetic peptide
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID Q7L266 (Human)
Synonym Isoaspartyl peptidase/L-asparaginase, EC 3.4.19.5, EC 3.5.1.1, Asparaginase-like protein 1, Beta-aspartyl-peptidase, Isoaspartyl dipeptidase, L-asparagine amidohydrolase [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain], ASRGL1, ALP, CRASH
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml; microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
ELISA Assay dependent
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)
Background

7B6 reacts with CRASH, a 308 AA glycoprotein sharing 32% homology with human asparaginase and identical to Asparaginase-Like Protein (ALP) found in rat sperm. CRASH is found in a variety of tumors, but only occasionally in normal tissues. Especially ovarian cancers are highly positive. CRASH is further found in brain tumors, some colonic cancers, some lung cancers, some prostate cancers, uterine cancers, some breast cancers and some thyroid cancers. It was not found in serum. In Western blot three bands are demonstrated of 45 kDa, 28 kDa and 15 kDa.

Positive control: ovarian cancer, KM22 breast cancer cells.

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