Epitope mapped
Disease related
Frequently used

anti-Desmoplakin 1/2 mouse monoclonal, DP1 + 2-2.15, purified, sample (ready-to-use)

Lyophilized

Sample

Cat. No: 61003S

Available, delivery time 1-7 days

$65.00*

Key Features
  • Purified, prediluted sample, ready-to-use for IHC
  • Mouse monoclonal
  • Suitable for ICC/IF, IHC and WB
  • Reacts with bovine, chicken, human, mouse, rat
  • Isotype: IgG1
Product description
Quantity 600 µl (ready-to-use)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Application ICC/IF, IHC, WB
Purification Affinity chromatography
Reactivity Bovine, Chicken, Human, Mouse, Rat
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone DP1 + 2-2.15
Immunogen Bovine desmoplakin 1 + 2
Formulation PBS pH 7.4 with 0.5% BSA and 0.09% sodium azide
UniprotID A0A3Q1MR22 (Bovine),E1BWI0 (Chicken),P15924 (Human),E9Q557 (Mouse),Q8VBY1 (Rat)
Synonym Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Applications
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) Assay dependent
Immunohistochemistry (IHC) - frozen Ready-to-use
Immunohistochemistry (IHC) - paraffin Ready-to-use (microwave treatment recommended)
Western Blot (WB) Assay dependent
Background

DP1 + 2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250,000 and 215,000).

The epitope recognized by clone DP1 + 2-2.15 is mapped to the N-terminus of the rod domain (Bornslaeger, E. A., 1996).

Bornslaeger, E. A. Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J. Cell Biol. 134, 985–1001 (1996).

References/Publications (18)
Publication
Species
Application
Downloads
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Category
Size
Filetype
Category Protocol
Size 924.86 KB
Filetype pdf
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