Disease related

anti-LRP1 (85kDa) mouse monoclonal, 5A6, lyophilized w/o sodium azide, purified

Cat. No: 61066

Available, delivery time 1-7 days

$293.00*

Key Features
  • Mouse monoclonal
  • Suitable for FACS, IHC and WB
  • Reacts with hamster, human, mouse, rabbit and rat
  • Isotype: IgG2b
Product description
Quantity 50 µg
Antibody Type Monoclonal
Host Mouse
Isotype IgG2b
Conjugate Unconjugated
Application FACS, IHC, WB
Purification Affinity chromatography
Reactivity Hamster, Human, Mouse, Rabbit, Rat
Storage before reconstitution 2-8°C until indicated expiry date
Storage after reconstitution Up to 3 months at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone 5A6
Immunogen Human LRP/alpha2MR
Concentration 50 µg/ml after reconstitution with 1 ml dist. water
Formulation Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:20
Immunohistochemistry (IHC) - paraffin 1:20 (microwave treatment recommended)
Flow Cytometry (FACS) Assay dependent
Western Blot (WB) Assay dependent
Background

5A6 specifically reacts with the 85 kDa b-chain of human LRP/a2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91). Neutralizing effects of 5A6 have also been reported (Basu et al., 2001).

Basu S, Binder RJ, Ramalingam T, Srivastave PK: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp 70, and calreticulin. Immunity 14, 303-313 (2001)

References/Publications (2)
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anti-LRP1 (85kDa) mouse monoclonal, 8B8, lyophilized w/o sodium azide, purified
Cat. No: 61067
  • Mouse monclonal
  • Suitable for FACS, ICC/IF, IHC and WB
  • Reacts with hamster, human, mouse, rabbit and rat
  • Isotype: IgG1

$293.00*
anti-LRP1 (515kDa) mouse monoclonal, 8G1, lyophilized w/o sodium azide, purified
Cat. No: 61065
  • Mouse monoclonal
  • Suitable for FACS, IHC and WB
  • Reacts with human
  • Isotype: IgG1

$293.00*