anti-MLH1 mouse monoclonal, IHC409, purified
- Mouse monoclonal
- Suitable for IHC
- Reacts with human
- Isotype: IgG2a
|Intended use||Research use only|
|Immunogen||Recombinant Human MLH1|
|Formulation||Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide|
|Synonym||DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2
|Tested applications||Tested dilutions|
|Immunohistochemistry (IHC) - paraffin||1:50-1:200 (microwave treatment recommended)|
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable.
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