Diagnostic marker

anti-MLH1 mouse monoclonal, IHC409, purified

Cat. No: 691743

Available, delivery time 1-7 days

$588.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC
  • Reacts with human
  • Isotype: IgG2a
Product description
Quantity 1 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Application IHC
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone IHC409
Immunogen Recombinant Human MLH1
Formulation Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide
UniprotID P40692 (Human)
Synonym DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - paraffin 1:50-1:200 (microwave treatment recommended)
Background
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable.
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