Diagnostic marker

anti-MSH2 mouse monoclonal, IHC410, purified

Cat. No: 691741

Available, delivery time 1-7 days

$588.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC
  • Reacts with human
  • Isotype: IgG2b
Product description
Quantity 1 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG2b
Conjugate Unconjugated
Application IHC
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone IHC410
Immunogen Recombinant Human MSH2
Formulation Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide
UniprotID P43246 (Human)
Synonym DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2

Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - paraffin 1:50-1:200 (microwave treatment recommended)
Background
MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.
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