Disease related
Frequently used

anti-Perilipin 2 (N-terminus) mouse monoclonal, AP125, lyophilized, purified

Liquid

Lyophilized

Liquid

Sample

Cat. No: 610102

Available, delivery time 1-7 days

$350.00*

Key Features
  • Purified, lyophilized
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with dog, human and rat
  • Isotype: IgG1
Product description
Quantity 50 µg
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Application IHC, WB
Purification Affinity chromatography
Reactivity Dog, Human, Rat
No reactivity Bovine
Storage before reconstitution 2-8°C until indicated expiry date
Storage after reconstitution Up to 3 months at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone AP125
Immunogen Synthetic peptide (aa 5-27 from N-terminus of human adipophilin/PLIN2)
Concentration 50 µg/ml after reconstitution with 1 ml dist. water
Formulation Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Synonym PLIN2, ADRP
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:10-1:100
Immunohistochemistry (IHC) - paraffin 1:10-1:100 (microwave treatment recommended)
Western Blot (WB) Assay dependent
Background

Perilipin 2/Adipophilin/ADRP/PLIN2 is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir.
Enhanced expression of Perilipin 2/Adipophilin/ADRP/PLIN2 is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis. ADRP can also be used to study virus entry via lipid droplets.
Polypeptide reacting: Perilipin 2/Adipophilin/ADRP/PLIN2, MW 48,100 (calculated from aa sequence data); apparent Mr 52,000 (after SDS-PAGE); pI 6.72.
Immunolocalization: Perilipin 2/Adipophilin/ADRP/PLIN2 is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculata of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative.Also positively stained are lipid-storing CD 68-positive macrophages.
Tested cultured cell lines: PLC, MDCK.

Learn more about PROGEN Perilipin antibodies.

References/Publications (1)
Publication
Species
Application
Downloads
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Category
Size
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Category Protocol
Size 924.86 KB
Filetype pdf
Category Protocol
Size 919.99 KB
Filetype pdf
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