Disease related

anti-Shigella dysenteriae Serotype 1 mouse monoclonal, EBS-I-106, purified

Cat. No: 691648

Available, delivery time 1-7 days

$425.00*

Key Features
  • Mouse monoclonal
  • Suitable for ELISA, ICC/IF and IHC
  • Reacts with S. dysenteriae
  • Isotype IgG3 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG3 kappa
Conjugate Unconjugated
Application ELISA, ICC/IF, IHC
Purification Affinity chromatography
Reactivity S. dysenteriae
Storage 2-8°C
Intended use Research use only
Clone EBS-I-106
Immunogen Total sonicate of Shigella dysenteriae NCTC 4837
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
Applications
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:100-1:200 (0.5-1.0 µg/ml)
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
ELISA Assay dependent
Background

EBS-I-106 reacts with a soluble extracted antigen from Shigella dysenteriae S1 in EIA. Shigellae are Gram-negative, non-spore-forming, facultative anaerobic, non-motile bacteria. S. dysenteriae is a species of the rod-shaped bacterial genus Shigella. This microbe is a normal inhabitant of the human gastrointestinal tract and can cause shigellosis (bacillary dysentery). This is the most severe dysentery mainly because of its potent and deadly Shiga toxin. Shiga toxins work by inhibiting protein synthesis in the host cells. After entering a cell, the Shiga toxin acts as an N-glycosidase, cleaving several nucleobases from the RNA that comprises the ribosome, thereby halting protein synthesis. The toxin has two subunits: A, which is internalized and cleaved into two parts, one of which binds to the ribosome, disrupting protein synthesis; and B, a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide. S. dysenteriae is spread through contaminated water and foodstrains are resistant to several antibiotics because of the presence of R factors in plasmids.

Positive control: S. dysenteriae S1 extract or infected cells or tissue, NCTC 4837.

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