Human Chimeric AAV Antibodies

Detect Antibodies against AAV
for Patient Safety

Patients can develop anti-AAV antibodies due to naturally occuring AAV infections. These antibodies can interfere with AAV vector gene transfer and the results can be unsafe or simply ineffective. To ensure patients are not put at unnecessary risk it is essential to test patient sera when selecting patients for AAV clinical trials.

Human chimeric AAV antibodies are a reliable assay control to be used when detecting AAV antibodies in human sera and are based on PROGEN’s exclusive portfolio of neutralizing anti-AAV mouse monoclonal antibodies. They have the same variable region, but the human chimeric AAV antibodies contain a human Fc region. This allows them to be recognized by anti-human secondary antibodies and ensure comparability with human serum antibodies.

Available for AAV1, AAV2, AAV3, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh10 and AAVrh74.

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Human Chimeric AAV Antibody Benefits

Ensure safety: testing patient sera before clinical trials ensures you know whether AAV antibodies are present in patient sera or not, resulting in a safe and efficient gene transfer.

Saves you time: avoid the time-intensive procedure of characterizing AAV-positive reference serum and get hold of an off-the shelf solution within days.

Adhere to FDA guidelines: pre-testing patient sera is not a nice-to-have, but imperative in adhering to FDA guidelines.

Achieve comparability: with their strong similarity to the human sample, these antibodies provide lot-to-lot consistency and comparability.

Sample sizes available: smaller 10 µg sizes allow you to trial and test to ensure the right fit for your next project.

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Cross-Reactivity

The human chimeric AAV antibodies show the same cross-reactivity as our established mouse monoclonal antibodies. Take a look at the chart below to find out where cross-reactivity is taking place.

Human Chimeric Antibody

Clone

AAV1

AAV2

AAV3

AAV4

AAV5

AAV6

AAV7

AAV8

AAV9

AAVrh10

AAVrh74

AAVDJ

Anti-AAV1

ADK1a-h1

X

n.a.*

Anti-AAV2

A20-h1

X

n.a.*

Anti-AAV5

ADK5b-h1

X

n.a.*

Anti-AAV5

ADK5b-h2

X

n.a.*

Anti-AAV8

ADK8-h1

X

Anti-AAV9

ADK9-h1

n.a.*

X

x - Reactivity
na - Not analysed
Empty field - no reactivity

What customers are saying

The human chimeric anti-AAV9 antibody has exceeded my expectations and it has picked up empty AAV9 capsid couples on Luminex beads. The development data shows the assay is working well and I would highly recommend using these antibodies in ELISAs or other bridging assays e.g. ADAs.

Scientific Specialist, Labcorp Drug Development

POSTER Human Chimeric AAV Antibodies – Advanced Standard for Serological Assays

Download our poster to explore characterization data of human chimeric AAV antibodies. Here we take a closer look at cross-reactivity, sensitivity and neutralizing activities in comparison with mouse monoclonal antibodies.

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