AAV Particle Antibodies
Recognize fully assembled
capsids easily
AAV particle antibodies recognize conformational epitopes on viral capsids that are only present on fully assembled capsids. These epitopes are made up of distant amino acids either from the same protein or from different proteins that are close by.
You can use particle antibodies to
Analyze: track the location of virus particles and identify protein-protein interactions
Purify: suitable for AAV particle purification using affinity chromatography
Characterize: determine your AAV capsid titers
Control: analyze the condition of your AAV particles
Monitor: use as a positive control for neutralization assays with patient sera
Cross Reactivity & Neutralization
All our AAV particle antibodies were tested for their cross-reactivity and some showed high cross-reactivity with other serotypes. Use the table below to see the cross reactivity.
Click on the buttons in the first column to get more product information including specific binding sites, neutralizing activity and available products.
Antibody Clone |
AAV1 |
AAV2 |
AAV3 |
AAV4 |
AAV5 |
AAV6 |
AAV7 |
AAV8 |
AAV9 |
AAVrh10 |
AAV11 |
AAV12 |
AAVrh74 |
Anc80 |
AAVDJ |
AAV2.7m8 |
ADK1a |
✓ | ✓ | ✓ | na | na | na | ||||||||||
A20 |
✓ | ✓ | na | na | ✓ | |||||||||||
A20R |
✓ | ✓ | ✓ | ✓ | ||||||||||||
ADK4 |
✓ | na | na | na | ||||||||||||
ADK5a |
✓ | na | na | na | ||||||||||||
ADK5b |
✓ | na | na | na | na | na | na | |||||||||
ADK6 |
✓ | na | na | na | ||||||||||||
ADK8 |
✓ | ✓ | ✓ | (✓) | ✓ | ✓ | na | |||||||||
ADK8/9 |
na | ✓ | (✓) | ✓ | na | na | ✓ | ✓ | (✓) | na | ||||||
| ADK9 | ✓ | na | na | na | na | |||||||||||
ADK9-1R |
na | ✓ | na | na | na | na | na | na |
✓ - Reactivity
(✓) - Weak Reactivity
na - Not analysed
Empty field - no reactivity
Data for assembled capsids AAV7/11/12 Under Courtesy of Regine Heilbronn, Charité Universitätsmedizin Berlin
Mietzsch et al. Hum Gene Ther. 2014 Mar 1; 25(3):212 222
What customers are saying
'All AAV primary antibodies I have ordered from PROGEN have been specific and reliable.'
Scientist I, ElevateBio
AlphaLISA® AAV2 Capsid Detection Kit
PerkinElmer has integrated PROGEN’s well-established AAV2 particle antibody A20R into their no-wash AlphaLISA® assay technology. The AlphaLISA® AAV2 Capsid Detection Kit is designed to quantify AAV2 capsids in buffer, cell culture media, cell lysates and cell supernatants.
PROGEN’s A20R antibody exclusively detects fully assembled, intact AAV2 capsids, providing an efficient and reliable quantification of the overall AAV2 capsid titer.
