Disease related

anti-p120 (catenin, delta-1 (TNND1; pTyr96)) mouse monoclonal, EBS-CA-011, purified

Cat. No: 691628

Available, delivery time 1-7 days

$425.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with human, mouse and rat
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application IHC, WB
Purification Affinity chromatography
Reactivity Human, Mouse, Rat
Storage 2-8°C
Intended use Research use only
Clone EBS-CA-011
Immunogen Mouse p120 catenin (pY96)
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID O60716 (Human), P30999 (Mouse), D3ZZZ9 (Rat)
Synonym Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn, p120(cas, CTNND1, KIAA0384
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)
Background

The membrane associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, pl20 catenin is localized to the E-cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 catenin directly associates with the cytoplasmic C-terminus of E-cadherin via its Arm domain and may similarly interact with other cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signalling molecules, such as PTP1C.

Positive control: carcinoma.

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