Disease related

anti-Perilipin 3 mouse monoclonal, 49.19, supernatant

Cat. No: 651168

Available, delivery time 1-7 days

$278.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with bovine, human, mouse and rat
  • Isotype: IgG1
Product description
Quantity 5 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Purification Hybridoma cell culture supernatant
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone 49.19
Immunogen Recombinant polypeptide of human TIP47 / PP17 / PLIN3
Formulation Contains 0.09% sodium azide
UniprotID Q3SX32 (Bovine),O60664 (Human),Q9DBG5 (Mouse),M0RA08 (Rat)
Synonym Perilipin-3, 47 kDa mannose 6-phosphate receptor-binding protein, 47 kDa MPR-binding protein, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1, Placental protein 17, PP17, PLIN3, M6PRBP1, TIP47
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen Undiluted - 1:10 (also after fixation with 2% PFA)
Immunohistochemistry (IHC) - paraffin Undiluted - 1:10 (microwave treatmtent recommended)
Western Blot (WB) Assay dependent (avoid use of milk proteins (e.g. dry milk preparations) in blocking and incubation buffers)
Background

TIP47 (tail-interacting protein of 47 kDa; also named Perilipin 3, PLIN3) is involved in lipid droplet maturation (see e.g. Bulankina 2003 and 2009). The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts of TIP47/PLIN3 are secreted into circulation of cervix carcinoma patients. After radical surgery PLIN3 serum levels are decreased (cf. Than et al. 1999).
TIP47/PLIN3 shows about 40% sequence homology to adipophilin (PLIN2). The antibody, however, is specific for TIP47/PLIN3 and does not cross-react with adipophilin (PLIN2) and perilipin (PLIN1) or other proteins of the PLIN/PAT family.
Reactivity on cultured cell lines: PLC, A431, HT29, HeLa, SV-80; human pre-adipocytes

Bulankina, A. V et al. TIP47 functions in the biogenesis of lipid droplets. J. Cell Biol. 185, 641-55 (2009).
Bulankina, A. V. TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function. Computing (2003).
Than, N. G., Sumegi, B., Than, G. N., Kispal, G. & Bohn, H. Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): Homology with adipophilin and the mouse adipose, differentiation-related protein. Tumor Biol. 20, 184-192 (1999).

References/Publications (1)
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